A COHORT STUDY ON MATERNAL AND NEONATAL OUTCOMES AFTER VAGINAL PROGESTERONE TREATMENT IN TWIN PREGNANCIES
Keywords:
Twin Pregnancies, Vaginal Progesterone Therapy, Maternal Outcomes, Preterm Birth, Neonatal Morbidity, Gestational Complications, Cohort Study, SwatAbstract
This cohort study investigated maternal and neonatal outcomes associated with vaginal progesterone therapy in twin pregnancies at Swat Medical College and its affiliated teaching hospitals in Saidu Sharif, Swat, between January 2022 and June 2024. A total of 300 women with twin gestations were enrolled, receiving either standard antenatal care or additional vaginal progesterone supplementation. Outcomes were evaluated in terms of preterm birth rates, neonatal morbidity, and maternal complications.
The results demonstrated that vaginal progesterone use was significantly associated with a reduction in preterm births (p < 0.05) and improved neonatal outcomes, including decreased incidences of respiratory distress and neonatal intensive care unit (NICU) admissions. No statistically significant differences were observed in maternal complications such as gestational hypertension or preeclampsia between the treatment and control groups.
These findings suggest that vaginal progesterone therapy may be an effective intervention for lowering the risk of preterm birth and enhancing neonatal health in twin pregnancies. Further large-scale studies are warranted to confirm these outcomes and explore the long-term implications for neonatal development.
